Dendrotoxin K

Dendrotoxins are a group of proteins found in the venom of the black mamba (Dendroaspis polylepis polylepis) and the eastern green mamba (Dendroaspis angusticeps). They belong to the bpti (bovine pancreatic trypsin inhibitor)/kunitz family of inhibitors. They also aid in the release of acetylcholine from presynaptic membranes of cholinergic synapses. Dendrotoxin K inhibits trypsin slightly, but it fails to inhibit chymotrypsin at all. However, dendrotoxin K is a selective blocker of voltage-gated potassium channels.
Dendrotoxin K is a 57 amino-acid residue long protein that contains three disulfide bonds: Cys5-Cys55, Cys14-Cys38, and Cys30-Cys51. This picture is colored by secondary structure: Alpha helices=Blue, beta sheets=yellow. The disulfide bonds are shown in white.


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