Cdc42Hs is a human placental intracellular G-protein involved in signaling pathways related to the structure of the cytoskeleton. Cdc42Hs belongs to the rho subfamily of ras-like GTP-binding proteins. These particular proteins are involved in several biological processes. One such process is directing the assembly of macromolecular complexes. This will ultimately have an effect on growth factor-stimulated cytoskeletal rearrangments and cellular morphological changes by controlling the formation of actin-dependent structures. Cdc42Hs specifically induces filopodia. In order to assist in this macromolecular assembly, the rho proteins must move to different locations throughout the cell, or between the plasma membrane and the cytosol. This movement of cellular location is coupled to the GTP-binding/GTPase activity of the proteins.
Cdc42Hs is 194 amino acid residues long. It shows 50% sequence identity to the proteins rhoA, rhoB, and rhoC. However, Cdc42Hs shows 80% sequence identity to the cell-division-cycle protein Cdc42Sc of the organism Saccharomyces cerevisiae, or yeast. The protein shown here is colored by secondary structure.