Epithelial or E-cadherin is a transmembrane protein. It provides epithelial cells with calcium-dependent cell-adhesion. The amino-terminal domain of E-cadherin matches the first out of five extracellular repeats. This domain is roughly 100 amino acid residues long. It consists of 7 beta strands (gold) and a single 310 alpha helix (purple). The secondary structure of the amino-terminal domain is characterized as a beta-barrel fold, similar to that of the immunoglobin fold.

• Keywords: Cadherin, Calcium-Binding, Cell Adhesion, Glycoprotein, Phosphorylation, Transmembrane, Repeat, Signal
  
• View this protein's PDB entry as 1SUH
• View this protein's SwissProt entry as CAD1_MOUSE
• References:
  • M. Overduin, K.I. Tong, C.M. Kay, M. Ikura
    1H, 15N, and 13C Resonance Assignments and Monomeric Structure of the Amino-Terminal Extracellular Domain of Epithelial Cadherin.
    J. Biomol. NMR 7:173 (1996)
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  • M. Overduin, T.S. Harvey, S. Bagby, K.I. Tong, P.Yau, M. Takeichi, M. Ikura
    Solution Structure of the Epithelial Cadherin Domain Responsible for Selective Cell Adhesion.
    Science 267:386 (1995)
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