Shc, SH2 Domain

The Shc transforming protein's function isn't fully understood, however, it may link activated growth factor receptors to a signaling pathway which in turn regulates the proliferation of mammalian cells. Also, this protein may play a role in the transformation of oncogenic tyrosine kinases. The SH2 domain shown here resides in the C terminal region of the protein. The SH2 domain, or Src homology-2 domain, are about 100 amino acid residues long and are found in intracellular signal-transduction proteins. This domain recognizes and binds phosphotyrosine-containing sequences with a high specificity in proteins that participate in signaling by growth factors and oncogenes.
The SH2 domain of Shc is 107 amino acid residues long. Its structure consists of 3 alpha-helices (gold) and 5 beta-strands (blue). The phosphopeptide that is shown in complex with the SH2 domain is 14 amino acid residues long and is as follows: Gly-His-Asp-Gly-Leu-pTyr-Gln-Gly-Leu-Ser-Thr-Ala-Thr-Lys.


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