Regulatory protein E2 from the Human Papillomavirus type 31, is a trans-acting transcriptional activator. The protein is capable of activating a conditional enhancer in the viral long control region, or lcr.
This domain of E2 binds DNA as a dimer and is sequence specific. It recognizes the palindromic sequence 5'-ACCGNNNCGGT-3'. Each subunit of E2 is 83 amino acid residues long. The overall secondary structure of the dimer consists of an eight-stranded beta-barrel (magenta) and two pairs of alpha-helices (purple).

• Keywords: Early Protein, Transcription Regulation, Transcriptional Activator, DNA-Binding Protein, Trans-Acting Factor, DNA Replication, Repressor, Nuclear Protein
• View this protein's PDB entry as 1DHM
• View this protein's SwissProt entry as VE2_HPV31
• References:
  • H. Liang, A.M. Petros, R.P. Meadows, H.S. Yoon, D.A. Egan, K. Walter, T.F. Holzman, T. Robins, S.W. Fesik
    Solution Structure of the DNA-Binding Domain of a Human Papillomavirus E2 Protein: Evidence for Flexible DNA-Binding Regions.
    Biochemistry 35:2095 (1996)
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