Human Papillomavirus E2 Protein, DNA-binding domain

Regulatory protein E2 from the Human Papillomavirus type 31, is a trans-acting transcriptional activator. The protein is capable of activating a conditional enhancer in the viral long control region, or lcr.
This domain of E2 binds DNA as a dimer and is sequence specific. It recognizes the palindromic sequence 5'-ACCGNNNCGGT-3'. Each subunit of E2 is 83 amino acid residues long. The overall secondary structure of the dimer consists of an eight-stranded beta-barrel (magenta) and two pairs of alpha-helices (purple).


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