Epidermal Growth Factor

Epidermal growth factor (EGF) is a small mitogenic protein that is thought to be involved in mechanisms such as normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and functional homology with human type-alpha transforming growth factor (hTGF alpha), which is a competitor for EGF receptor sites. EGF is a small 53 amino acid residue long protein that contains three disulfide briges.
EGF is colored by secondary structure.


This is a picture of EFG with three disulfide bridges visible and important side chains visible:

The three disulfide bridges are colored yellow and are as folows: Cys6-Cys20, Cys14-Cys31, and Cys33-Cys42. The protein itself is colored by chain. The side chains of residues 13 (Tyr),41 (Arg), and 47 (Leu) are all thought to play an important role in EGF's functionality.


Another conformer of EGF


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