RBP-MS RNA-binding domain, homology model
The human RNA-binding protein with multiple splice sites (RBP-MS) has been constructed using homology modeling. The homology model depicts the RNA-binding domain of RBP-MS. The template protein which RBP-MS was modeled after is snRNP (small nuclear RiboNuclear Protein) U1A, specifically the N terminal RNA-binding region of snRNP U1A. The RNA-binding domain of RBP-MS shares about 22% sequence identity with snRNP U1A.
The RNA-binding domain of RBP-MS is 97 amino acid residues long, and it is an alpha-beta protein. It consists of 3 alpha-helices (purple) and 4 beta-sheets (seagreen). The function of the RBP-MS gene is not yet known.
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- Keywords: Human Rbp-Ms, Homology Modeling, Werner's Syndrome, RNA-Binding Protein
- View this protein's PDB entry as 1BNY
- P.V. Sahasrabudhe, R. Tejero, S. Kitao, Y. Furuichi, G.T. Montelione
Homology Modeling of an RNP Domain From a Human RNA-Binding Protein: Homology-Constrained Energy Optimization Provides a Criterion for Distinguishing Potential Sequence Alignments.
To be published
- A. Shimamoto, S. Kitao, K. Ichikawa, N. Suzuki, Y. Yamabe, O. Imamura, Y. Tokutake, M. Satoh, T. Matsumoto, J. Kuromitsu, H. Kataoka, K. Sugawara, M. Sugawara, M. Sugimoto, M. Goto, Y. Furuichi
A Unique Human Gene That Spans Over 230 kB in the Human Chromosome 8p11-12 and Codes Multiple Family Proteins Sharing RNA-Binding Motifs.
Proc. Nat. Acad. Sci. USA 93:10913 (1996)
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