Tendamistat

Tendamistat is a protein which specifically inhibits mammalian alpha-amylases. It forms a strong stoichiometric 1:1 complex with the enzyme alpha-amylase. This protein however, has no effect on the alpha-amylases of plants or microbes.
Tendamistat is 74 amino acid residues long. The only secondary structure found in the protein are six beta sheets shown here in blue. The protein also contains two disulfide bridges; Cys11-Cys27 and Cys45-Cys73 which are shown in pink.

• Keywords: Alpha-Amylase Inhibitor, Signal
• View this protein's PDB entry as 4AIT
• View this protein's SwissProt entry as IAA_STRTE
• References:
  • M. Billeter ,T. Schaumann, W. Braun, K. Wuthrich
    Restrained Energy Refinement With Two Different Algorithms and Force Fields of the Structure of the Alpha-Amylase Inhibitor Tendamistat Determined by NMR in Solution
    Biopolymers 29:695 (1990)
    
  • A.D. Kline, W. Braun, K. Wuthrich
    Determination of the Complete Three-Dimensional Structure of the Alpha-Amylase Inhibitor Tendamistat in Aqueous Solution by Nuclear Magnetic Resonance and Distance Geometry.
    J. Mol. Biol. 204:675 (1988)
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  • A.D. Kline, K. Wuthrich
    Complete Sequence-Specific 1H Nuclear Magnetic Resonance Assignments for the Alpha-Amylase Polypeptide Inhibitor Tendamistat From Streptomyces tendae.
    J. Mol. Biol. 192:869 (1986)
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  • A.D. Kline, W.Braun, K. Wuthrich
    Studies by 1H Nuclear Magnetic Resonance and Distance Geometry of the Solution Conformation of Tendamistat, an Alpha Amylase Inhibitor.
    J. Mol. Biol. 189:377 (1986)
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  • A.D. Kline, K. Wuthrich
    Secondary Structure of the Alpha-Amylase Polypeptide Inhibitor Tendamistat From Streptomyces tendae Determined in Solution by 1H Nuclear Magnetic Resonance.
    J. Mol. Biol. 183:503 (1985)
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