NIGMS Protein Structure Initiative
Workshop on Target Selection
Conference Room D, Natcher Building, NIH
November 13 – 14, 2003


Thursday, November 13
8:00 Refreshment
8:30 Significance of Target Selection for the PSI (John Norvell)
Critical Questions in Target Selection (John Moult)
9:00 Session I: Genome Coverage Based Target Selection
Session Chair:  Cathy Wu
9:00 Target Selection Overview (Chris Sander)
9:30 Protein Family and Evolution (Cyrus Chothia)
9:55 Pan-Genome Analysis (Andrej Sali)
10:20 Break
10:50 Genome Analysis to Select Targets which Probe Fold and Function Space (Christine Orengo)
Eukaryotic Genome Analysis (Burkhard Rost)
11:40 Prokaryotic Genome Analysis (John Moult)
12:05 Pfam family and Structural Genomics (Steven Brenner)
12:30 Lunch
1:30 Session II: Biomedical Interest in Target Selection    
Session Chair:  Ed Lattman
1:30 Overview (Wayne Hendrickson)
2:00 How to Balance Biology and Fold Space Coverage? (David Eisenberg)
2:25 Target Selection Relevant to Health (Wim Hol)
2:50 Human Kinome (Susan Taylor)
3:15 Break
3:45 Single Organism Target: Minimal Genomes (Sung-Hou Kim)
4:10 Single Organism Target: Arabidopsis Genome(John Markley)
4:35 Single Organism Target: Mouse Genome (Adam Godzik)
6:30 Dinner

Friday, November 14

8:30 Session III:  Problem Areas in Target Selection                                       
Session Chair:  David Davies
8:30 Networks and Complexes (Jack Greenblatt)
8:55 Integration of Multiple Genomes (Bi-Cheng Wang)
9:20 Membrane Proteins (Doug Rees)
9:45 Milestones and Metrics (Stephen Burley)
10:15 Break
10:45 Session IV:  Final Discussion
Session Chair: Chris Sander/Brian Matthews
12:00 Workshop Adjourn