Biochemistry 694:412
Proteomics and Functional Genomics
Spring 2004
CABM 208
9:50 - 11:10 AM

Syllabus of Lectures

Date
Topic
Lecturer
Jan. 20th
Course introduction and overview of genomics and proteomics [HTML] [PPT]
GM + SA
Jan. 23rd
Overview of genomics and proteomics (cont'd) [HTML] [PPT]
Reading Assignment 1, Reading Assignment 2
SA



Jan. 27th Protein folding [HTML] [PPT]
Reading Assignment 1, Reading Assignment 2, Reading Assignment 3
SA
Jan. 30th
Tools of bioinformatics: Blast, PsiBlast, DNA sequence databases [HTML] [PPT]
Reading Assignment
GM



Feb. 3rd
Comparative biology based on genomic sequence analysis [HTML] [PPT]
Reading Assignment
GM
Feb. 6th
Conformational properties of proteins [PPT]
Reading Assignment
GM



Feb. 10th
Protein sequence and structure databases [HTML] [PPT]
Reading Assignment 1, Optional Reading 1, Optional Reading 2
GM
Feb. 13th
Exam I




Feb. 17th
Analytical and preparative protein chemistry I [HTML] [PPT]
Reading Assignment
SA
Feb. 20th
Analytical and preparative protein chemistry II [HTML] [PPT] SA



Feb. 24th
Protein mass spectrometry [HTML] [PPT]
Reading Assignment 1 (pp. 438-447)  Reading Assignment 2 (pp. 415-419)
SA
Feb. 27th
Biophysics of amide HD exchange [HTML] [PPT]
Reading Assignment 1, Reading Assignment 2, Optional Reading 1, Optional Reading 2, Optional Reading 3
GM



Mar. 2nd
Protein NMR spectroscopy I [HTML] [PPT] GM
Mar. 5th
Protein-protein interactions I [PPT]
Reading Assignment 1, Reading Assignment 2, Reading Assignment 3
SA



Mar. 9th
Protein NMR spectroscopy II [HTML] [PPT]
Reading Assignment
GM
Mar. 12th
Exam II




Mar. 16th
Spring Break

Mar. 19th
Spring Break




Mar. 23rd
Protein-protein interactions II [HTML] [PPT]
Reading Assignment
SA
Mar. 26th
Enzyme Kinetics I [HTML] [PPT]
Reading Assignment
GM



Mar. 30th
Protein X-ray Crystallography [HTML] [PPT]
Reading Assignment
Dr. Kalyan Das
Apr. 2nd
Enzyme kinetics II
GM



Apr. 6th
DNA microarrays [HTML] [PPT]
Reading Assignment
SA
Apr. 9th
RNA intereference[HTML] [PPT]
Reading Assignment
SA



Apr. 13th
No lecture

Apr. 16th
No lecture



Apr. 20th
Structure Genomics I + II (double lecture 9:30 am - noon) [HTML] [PPT]
Reading Assignment 1, Reading Assignment 2, Reading Assignment 3
GM
Apr. 23rd
Student Presentations
[Tong, Boone et al 2004(pdf)] [Brooijmans et al 2002(pdf)] [Friedman 2004(pdf)] [Hazbun et al 2003(pdf)] [Jansen et al 2003(pdf)]
[Lee et al 2002(pdf)] [Li et al 2004(pdf)] [Liu et al 2002(pdf)] [Matagne et al 1998(pdf)] [Milo et al 2002(pdf)]
Kate Drahos, HTP Protein-Protein Interaion Analysis [HTML] [PPT]
Dan Kulp, Macromolecular Complexes [HTML] [PPT]




Apr. 27th
Student Presentations
Apr. 30th
Student Presentations

*NOTE: EXAM III, COVERING THE LECTURES FROM MARCH 23rd TO APRIL 20th, INCLUSIVE, WILL BE GIVEN DURING THE FINAL EXAM PERIOD.