The CABM Structural Bioinformatics Laboratory carries out structure and function studies of genomically-defined protein targets. The lab uses both NMR and X-ray crystallography, along with computational methods, to address questions emerging from genomic and functional genomic analyses. The lab also develops software to automate structure determination by NMR methods. It is one of the principal nodes of the United States Protein Structure Initiative.
- Nature Methods: Solving Large Protein Structures By NMR. Two papers address this challenge by presenting hybrid methods that couple sparse NMR information with alternative structural information in order to solve protein structures. Read the full article here: Nature Methods
IN THE NEWS: A New Study Provides Key Insights into Aspirin's Disease-Fighting Abilities The lab of Gaetano Montelione in collaboration with colleagues at Cornell University-affiliated Boyce Thompson Institute (BTI) and Italy’s San Raffaele University and Research Institute, show that aspirin’s main breakdown product, salicylic acid, blocks the protein, HMGB1, which could explain many of the drug’s therapeutic properties. Read the full publication here: Molecular Medicine